Real-time sensing of MAPK signaling in medulloblastoma cells reveals cellular evasion mechanism counteracting dasatinib blockade of ERK activation during invasion

Real-time sensing of MAPK signaling in medulloblastoma cells reveals cellular evasion mechanism counteracting dasatinib blockade of ERK activation during invasion

Aberrantly activated kinase signaling pathways drive invasion and dissemination in medulloblastoma (MB). A majority of tumor-promoting kinase signaling pathways feed into the mitogen-activated protein kinase (MAPK) extracellular regulated kinase (ERK1/2) pathway. The activation status of ERK1/2 duri...

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Bibliographic Details
Main Authors: Marc Thomas Schönholzer, Jessica Migliavacca, Elena Alvarez, Karthiga Santhana Kumar, Anuja Neve, Alexandre Gries, Min Ma, Michael A. Grotzer, Martin Baumgartner
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Medulloblastoma
Nuclear ERK1/2 activation sensor
Cell migration
Cerebellum slice culture
Fluorescent biosensor
Live cell imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301378

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http://www.sciencedirect.com/science/article/pii/S1476558620301378

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