Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa

Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa

Next-generation and Sanger sequencing were combined to identify disease-causing USH2A mutations in an adult patient with autosomal recessive RP. Induced pluripotent stem cells (iPSCs), generated from the patient’s keratinocytes, were differentiated into multi-layer eyecup-like structures with featur...

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Bibliographic Details
Main Authors: Budd A Tucker, Robert F Mullins, Luan M Streb, Kristin Anfinson, Mari E Eyestone, Emily Kaalberg, Megan J Riker, Arlene V Drack, Terry A Braun, Edwin M Stone
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-08-01
Series:eLife
Subjects:
next-generation sequencing
retinal degeneration
induced pluripotent stem cell
retinal transplantation
retinal cell differentiation
retinitis pigmentosa
Online Access:https://elifesciences.org/articles/00824

Internet

https://elifesciences.org/articles/00824

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