Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91–106

Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91–106

Conformational conversion of the cellular prion protein, PrP<sup>C</sup>, into the abnormally folded isoform, PrP<sup>Sc</sup>, is a key pathogenic event in prion diseases. However, the exact conversion mechanism remains largely unknown. Transgenic mice expressing PrP with a...

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Bibliographic Details
Main Authors: Keiji Uchiyama, Hironori Miyata, Yoshitaka Yamaguchi, Morikazu Imamura, Mariya Okazaki, Agriani Dini Pasiana, Junji Chida, Hideyuki Hara, Ryuichiro Atarashi, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
prions
prion protein
protein misfolding
neurodegeneration
transgenic mice
Online Access:https://www.mdpi.com/1422-0067/21/19/7260

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https://www.mdpi.com/1422-0067/21/19/7260

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