Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160
Laminin-111 protein complex links the extracellular matrix to integrin α7β1 in sarcolemma, thus replacing in dystrophic muscles links normally insured by the dystrophin complex. Laminin-111 injection in mdx mouse stabilized sarcolemma, restored serum creatine kinase to wild-type levels, and protecte...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-03-01
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Series: | Molecular Therapy: Nucleic Acids |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253116303614 |