Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1

Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1

To study the role of Aβ amyloid deposits in the generation of cytoskeletal lesions, we have generated a transgenic mouse line coexpressing in the same neurons a wild-type human tau isoform (0N3R), a mutant form of APP (751SL) and a mutant form of PS1 (M146L). These mice developed early cerebral extr...

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Bibliographic Details
Main Authors: Allal Boutajangout, Michèle Authelet, Véronique Blanchard, N Touchet, Gunter Tremp, Laurent Pradier, Jean-Pierre Brion
Format: Article
Language:English
Published: Elsevier 2004-02-01
Series:Neurobiology of Disease
Subjects:
Transgenic
Tau
Presenilin 1
APP
Mutation
Alzheimer
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001967

Internet

http://www.sciencedirect.com/science/article/pii/S0969996103001967

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