Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

The integrated stress response (ISR) is activated by diverse forms of cellular stress, including endoplasmic reticulum (ER) stress, and is associated with diseases. However, the molecular mechanism(s) whereby the ISR impacts on differentiation is incompletely understood. Here, we exploited a mouse m...

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Bibliographic Details
Main Authors: Cheng Wang, Zhijia Tan, Ben Niu, Kwok Yeung Tsang, Andrew Tai, Wilson C W Chan, Rebecca L K Lo, Keith K H Leung, Nelson W F Dung, Nobuyuki Itoh, Michael Q Zhang, Danny Chan, Kathryn Song Eng Cheah
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
endoplasmic reticulum stress
integrated stress response
chondrodysplasia
protein kinase RNA-like ER kinase pathway
ATF4
ISRIB
Online Access:https://elifesciences.org/articles/37673

Internet

https://elifesciences.org/articles/37673

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