Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug Against H<sub>2</sub>O<sub>2</sub>-Induced Cellular Toxicity

Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug Against H<sub>2</sub>O<sub>2</sub>-Induced Cellular Toxicity

The L-3,4-dihydroxyphenylalanine (LD) is the gold standard drug currently used to manage Parkinson&#8217;s disease (PD) and to control its symptoms. However, LD could cause disease neurotoxicity due to the generation of pro-oxidant intermediates deriving from its autoxidation. In order to overco...

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Bibliographic Details
Main Authors: Sara Franceschelli, Paola Lanuti, Alessio Ferrone, Daniela Maria Pia Gatta, Lorenza Speranza, Mirko Pesce, Alfredo Grilli, Ivana Cacciatore, Emanuela Ricciotti, Antonio Di Stefano, Sebastiano Miscia, Mario Felaco, Antonia Patruno
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Antioxidants
Subjects:
L-Dopa
glutathione
SH-SY5Y cell line
U-937 cell line
Parkinson’s disease
ROS
apoptosis
Online Access:https://www.mdpi.com/2076-3921/8/8/319

Internet

https://www.mdpi.com/2076-3921/8/8/319

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