Huntington's disease CAG trinucleotide repeats in pathologically confirmed post-mortem brains

Huntington's disease CAG trinucleotide repeats in pathologically confirmed post-mortem brains

CAG repeat expansion in the Huntington's disease gene (HD) was examined in postmortem brains from 310 clinically diagnosed and 15 ‘at risk’ individuals. Presence of an expanded CAG allele (>37 units) was the cause of the disorder in almost all cases (307 of 310). Despite a diversity of repor...

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Bibliographic Details
Main Authors: Francesca Persichetti, Jayalakshmi Srinidhi, Lisa Kanaley, Pei Ge, Richard H. Myers, Kenneth D'Arrigo, Glenn T. Barnes, Marcy E. MacDonald, Jean-Paul Vonsattel, James F. Gusella, Edward D. Bird
Format: Article
Language:English
Published: Elsevier 1994-12-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
mutation
neuropathology
phenocopy
post-mortem brain
trinucleotide repeat
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996184700192

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http://www.sciencedirect.com/science/article/pii/S0969996184700192

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