The effect of infliximab in patients with chronic low back pain and Modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial

The effect of infliximab in patients with chronic low back pain and Modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial

Abstract Background Low back pain is common and a significant number of patients experience chronic low back pain. Current treatment options offer small to moderate effects. Patients with vertebral bone marrow lesions visualized as Modic changes on magnetic resonance imaging may represent a subgroup...

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Main Authors: Elisabeth Gjefsen, Lars Christian Haugli Bråten, Guro Løvik Goll, Monica Wigemyr, Nils Bolstad, Morten Valberg, Elina Iordanova Schistad, Gunn Hege Marchand, Fredrik Granviken, Kaja Kristine Selmer, Anne Froholdt, Anne Julsrud Haugen, Magnhild Hammersland Dagestad, Nils Vetti, Gunnstein Bakland, Benedicte Alexandra Lie, Espen A. Haavardsholm, Aksel Thuv Nilsen, Thor Einar Holmgard, Thomas Istvan Kadar, Tore Kvien, Jan Sture Skouen, Lars Grøvle, Jens Ivar Brox, Ansgar Espeland, Kjersti Storheim, John Anker Zwart
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Musculoskeletal Disorders
Subjects:
Low back pain
Modic changes
Inflammation
Clinical trial
TNF- α inhibitor
Infliximab
Online Access:http://link.springer.com/article/10.1186/s12891-020-03720-5

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http://link.springer.com/article/10.1186/s12891-020-03720-5

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