Different Apoptotic Pathways Activated by Oxaliplatin in Primary Astrocytes vs. Colo-Rectal Cancer Cells

Different Apoptotic Pathways Activated by Oxaliplatin in Primary Astrocytes vs. Colo-Rectal Cancer Cells

Oxaliplatin-based chemotherapy improves the outcomes of metastatic colorectal cancer patients. Its most significant and dose-limiting side effect is the development of a neuropathic syndrome. The mechanism of the neurotoxicity is unclear. The limited knowledge about differences existing between neu...

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Bibliographic Details
Main Authors: Matteo Zanardelli, Laura Micheli, Raffaella Nicolai, Paola Failli, Carla Ghelardini, Lorenzo Di Cesare Mannelli
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
glia
HT-29
neuropathic pain
intrinsic apoptotic pathway
extrinsic apoptotic pathway
oxaliplatin
Online Access:http://www.mdpi.com/1422-0067/16/3/5386

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http://www.mdpi.com/1422-0067/16/3/5386

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