Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activities in the oxidation of the C27 steroid side chain in bile acid formation

Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activities in the oxidation of the C27 steroid side chain in bile acid formation

We have examined the ability of HepG2 human hepatoblastoma cells and 7800 C1 Morris rat hepatoma cells to convert 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid (THCA) and 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid (DHCA) to cholic acid and chenodeoxycholic acid, respectivel...

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Bibliographic Details
Main Authors: Ann-Kristin Östlund Farrants, Astrid Nilsson, Jan I. Pedersen
Format: Article
Language:English
Published: Elsevier 1993-12-01
Series:Journal of Lipid Research
Subjects:
peruxisomal oxidation
3α,7α-dihydmxy-5β-cholestanoic acid
3α,7α,12α-trihydmxy-5β-cholestanoic acid
3α,7α,12α-trihydroxy-5β-cholest-24-enoic acid
cholesterol 7α-hydroxylase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520353463

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