Adaptive evolution of HIV at HLA epitopes is associated with ethnicity in Canada.

Adaptive evolution of HIV at HLA epitopes is associated with ethnicity in Canada.

Host immune selection pressure influences the development of mutations that allow for HIV escape. Mutation patterns induced in HIV by the human leukocyte antigen (HLA) are HLA-allele specific. As ethnic groups have distinct and characteristic HLA allele frequencies, we can expect divergent viral evo...

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Bibliographic Details
Main Authors: Manon Ragonnet-Cronin, Stéphane Aris-Brosou, Isabelle Joanisse, Harriet Merks, Dominic Vallee, Kyna Caminiti, Paul Sandstrom, James Brooks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3365047?pdf=render

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http://europepmc.org/articles/PMC3365047?pdf=render

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