Exposure to the Methylselenol Precursor Dimethyldiselenide Induces a Reductive Endoplasmic Reticulum Stress in <i>Saccharomyces cerevisiae</i>

Exposure to the Methylselenol Precursor Dimethyldiselenide Induces a Reductive Endoplasmic Reticulum Stress in <i>Saccharomyces cerevisiae</i>

Methylselenol (MeSeH) is a major cytotoxic metabolite of selenium, causing apoptosis in cancer cells through mechanisms that remain to be fully established. Previously, we demonstrated that, in <i>Saccharomyces cerevisiae</i>, MeSeH toxicity was mediated by its metabolization into seleno...

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Bibliographic Details
Main Authors: Marc Dauplais, Pierre Mahou, Pierre Plateau, Myriam Lazard
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
selenium
methylselenol
dimethyldiselenide
ER stress
reductive stress
unfolded protein response
Online Access:https://www.mdpi.com/1422-0067/22/11/5467

Internet

https://www.mdpi.com/1422-0067/22/11/5467

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