Kinetics of TNF-alpha and IFN-gamma mRNA expression in islets and spleen of NOD mice

Kinetics of TNF-alpha and IFN-gamma mRNA expression in islets and spleen of NOD mice

Insulin-dependent diabetes mellitus is caused by autoimmune destruction of pancreatic ß cells. Non-obese diabetic (NOD) mice spontaneously develop diabetes similar to the human disease. Cytokines produced by islet-infiltrating mononuclear cells may be directly cytotoxic and can be involved in islet...

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Bibliographic Details
Main Authors: D. Ventura-Oliveira, C.A. Vilella, M.E. Zanin, G.M. Castro, D.C. Moreira Filho, R.L. Zollner
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2002-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Diabetes
NOD mice
Cytokines
RT-PCR
Pancreatic islets
Time course
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100013

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100013

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