The vitamin D receptor agonist BXL-01-0029 as a potential new pharmacological tool for the treatment of inflammatory myopathies.

The vitamin D receptor agonist BXL-01-0029 as a potential new pharmacological tool for the treatment of inflammatory myopathies.

OBJECTIVE: This study aims to investigate in vitro the effect of the VDR agonist BXL-01-0029 onto IFNγ/TNFα-induced CXCL10 secretion by human skeletal muscle cells compared to elocalcitol (VDR agonist), methylprednisolone, methotrexate, cyclosporin A, infliximab and leflunomide; to assess in vivo ci...

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Bibliographic Details
Main Authors: Luigi Di Luigi, Mariangela Sottili, Cristina Antinozzi, Gabriella Barbara Vannelli, Francesco Romanelli, Valeria Riccieri, Guido Valesini, Andrea Lenzi, Clara Crescioli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3813757?pdf=render

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http://europepmc.org/articles/PMC3813757?pdf=render

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