In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin.

In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin.

The innate immune system is of vital importance for protection against infectious pathogens. Inflammasome mediated caspase-1 activation and subsequent release of pro-inflammatory cytokines like IL-1beta and IL-18 is an important arm of the innate immune system. Salmonella enterica subspecies 1 serov...

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Bibliographic Details
Main Authors: Claudia Hoffmann, Marlies Galle, Sabrina Dilling, Rina Käppeli, Andreas J Müller, Pascal Songhet, Rudi Beyaert, Wolf-Dietrich Hardt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2930008?pdf=render

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http://europepmc.org/articles/PMC2930008?pdf=render

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