The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivo.

The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivo.

BACKGROUND: After ischemia of the CNS, extracellular adenosine 5'-triphosphate (ATP) can reach high concentrations due to cell damage and subsequent increase of membrane permeability. ATP may cause cellular degeneration and death, mediated by P2X and P2Y receptors. METHODOLOGY/PRINCIPAL FINDING...

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Bibliographic Details
Main Authors: Alexandra B Lämmer, Alexander Beck, Benjamin Grummich, Annette Förschler, Thomas Krügel, Thomas Kahn, Dietmar Schneider, Peter Illes, Heike Franke, Ute Krügel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3096654?pdf=render

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http://europepmc.org/articles/PMC3096654?pdf=render

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