Shikimic Acid Inhibits Osteoclastogenesis in Vivo and in Vitro by Blocking RANK/TRAF6 Association and Suppressing NF-κB and MAPK Signaling Pathways

Shikimic Acid Inhibits Osteoclastogenesis in Vivo and in Vitro by Blocking RANK/TRAF6 Association and Suppressing NF-κB and MAPK Signaling Pathways

Background/Aims: Bone homeostasis is associated with the balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Unbalanced bone homeostasis as a result of reduced osteogenesis or excessive osteoclastogenesis can lead to disorders such as osteoporosis, Paget’s disease, and rheumatoi...

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Bibliographic Details
Main Authors: Xiao Chen, Xiaoqun Li, Xiao Zhai, Xin Zhi, Liehu Cao, Longjuan Qin, Jiacan Su
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
NFATc1
Shikimic acid
Postmenopausal osteoporosis
Osteoclasts
Online Access:https://www.karger.com/Article/FullText/496039

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https://www.karger.com/Article/FullText/496039

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