Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age.

Differentiating pluripotent cells from fibroblast progenitors is a potentially transformative tool in personalized medicine. We previously identified relatively greater success culturing dura-derived fibroblasts than scalp-derived fibroblasts from postmortem tissue. We hypothesized that these differ...

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Bibliographic Details
Main Authors: Nikolay A Ivanov, Ran Tao, Joshua G Chenoweth, Anna Brandtjen, Michelle I Mighdoll, John D Genova, Ronald D McKay, Yankai Jia, Daniel R Weinberger, Joel E Kleinman, Thomas M Hyde, Andrew E Jaffe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4767228?pdf=render