Exploiting orthology and de novo transcriptome assembly to refine target sequence information

Exploiting orthology and de novo transcriptome assembly to refine target sequence information

Abstract Background The ability to generate recombinant drug target proteins is important for drug discovery research as it facilitates the investigation of drug-target-interactions in vitro. To accomplish this, the target’s exact protein sequence is required. Public databases, such as Ensembl, UniP...

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Bibliographic Details
Main Authors: Julia F. Söllner, Germán Leparc, Matthias Zwick, Tanja Schönberger, Tobias Hildebrandt, Kay Nieselt, Eric Simon
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Medical Genomics
Subjects:
RNA-Seq
de novo transcriptome assembly
Orthology
Sequence refinement
Comparative genomics
Online Access:http://link.springer.com/article/10.1186/s12920-019-0524-5

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http://link.springer.com/article/10.1186/s12920-019-0524-5

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