Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.

Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.

BACKGROUND:Lewy body disease is a heterogeneous group of neurodegenerative disorders characterized by alpha-synuclein accumulation that includes dementia with Lewy bodies (DLB) and Parkinson's Disease (PD). Recent evidence suggests that impairment of lysosomal pathways (i.e. autophagy) involved...

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Bibliographic Details
Main Authors: Leslie Crews, Brian Spencer, Paula Desplats, Christina Patrick, Amy Paulino, Edward Rockenstein, Lawrence Hansen, Anthony Adame, Douglas Galasko, Eliezer Masliah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2824828?pdf=render

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http://europepmc.org/articles/PMC2824828?pdf=render

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