Mechanistic Insight Into the Roles of Integrins in Osteoarthritis
Osteoarthritis (OA), one of the most common degenerative diseases, is characterized by progressive degeneration of the articular cartilage and subchondral bone, as well as the synovium. Integrins, comprising a family of heterodimeric transmembrane proteins containing α subunit and β subunit, play es...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.693484/full |
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doaj-ea264869a73f423eb93fc39ed34cd9392021-06-18T06:58:27ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-06-01910.3389/fcell.2021.693484693484Mechanistic Insight Into the Roles of Integrins in OsteoarthritisHongfu Jin0Hongfu Jin1Shigang Jiang2Ruomei Wang3Yi Zhang4Yi Zhang5Jiangtao Dong6Yusheng Li7Yusheng Li8Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Endocrinology and Metabolic Diseases, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaOsteoarthritis (OA), one of the most common degenerative diseases, is characterized by progressive degeneration of the articular cartilage and subchondral bone, as well as the synovium. Integrins, comprising a family of heterodimeric transmembrane proteins containing α subunit and β subunit, play essential roles in various physiological functions of cells, such as cell attachment, movement, growth, differentiation, and mechanical signal conduction. Previous studies have shown that integrin dysfunction is involved in OA pathogenesis. This review article focuses on the roles of integrins in OA, especially in OA cartilage, subchondral bone and the synovium. A clear understanding of these roles may influence the future development of treatments for OA.https://www.frontiersin.org/articles/10.3389/fcell.2021.693484/fullintegrinosteoarthritiscartilagesubchondral bonemechanical signal conductionsynovial membrane |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hongfu Jin Hongfu Jin Shigang Jiang Ruomei Wang Yi Zhang Yi Zhang Jiangtao Dong Yusheng Li Yusheng Li |
| spellingShingle |
Hongfu Jin Hongfu Jin Shigang Jiang Ruomei Wang Yi Zhang Yi Zhang Jiangtao Dong Yusheng Li Yusheng Li Mechanistic Insight Into the Roles of Integrins in Osteoarthritis Frontiers in Cell and Developmental Biology integrin osteoarthritis cartilage subchondral bone mechanical signal conduction synovial membrane |
| author_facet |
Hongfu Jin Hongfu Jin Shigang Jiang Ruomei Wang Yi Zhang Yi Zhang Jiangtao Dong Yusheng Li Yusheng Li |
| author_sort |
Hongfu Jin |
| title |
Mechanistic Insight Into the Roles of Integrins in Osteoarthritis |
| title_short |
Mechanistic Insight Into the Roles of Integrins in Osteoarthritis |
| title_full |
Mechanistic Insight Into the Roles of Integrins in Osteoarthritis |
| title_fullStr |
Mechanistic Insight Into the Roles of Integrins in Osteoarthritis |
| title_full_unstemmed |
Mechanistic Insight Into the Roles of Integrins in Osteoarthritis |
| title_sort |
mechanistic insight into the roles of integrins in osteoarthritis |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Cell and Developmental Biology |
| issn |
2296-634X |
| publishDate |
2021-06-01 |
| description |
Osteoarthritis (OA), one of the most common degenerative diseases, is characterized by progressive degeneration of the articular cartilage and subchondral bone, as well as the synovium. Integrins, comprising a family of heterodimeric transmembrane proteins containing α subunit and β subunit, play essential roles in various physiological functions of cells, such as cell attachment, movement, growth, differentiation, and mechanical signal conduction. Previous studies have shown that integrin dysfunction is involved in OA pathogenesis. This review article focuses on the roles of integrins in OA, especially in OA cartilage, subchondral bone and the synovium. A clear understanding of these roles may influence the future development of treatments for OA. |
| topic |
integrin osteoarthritis cartilage subchondral bone mechanical signal conduction synovial membrane |
| url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.693484/full |
| work_keys_str_mv |
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