Chronic Tear Deficiency Sensitizes Transient Receptor Potential Vanilloid 1-Mediated Responses in Corneal Sensory Nerves

Chronic tear deficiency enhances the excitability of corneal cold-sensitive nerves that detect ocular dryness, which can lead to discomfort in patients with dry eye disease (DED). However, changes in corneal nerve excitations through the polymodal nociceptor “transient receptor potential vanilloid 1...

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Bibliographic Details
Main Authors: Takayoshi Masuoka, Yuka Yamashita, Katsuya Nakano, Kenshi Takechi, Takahiro Niimura, Masashi Tawa, Qiang He, Keisuke Ishizawa, Takaharu Ishibashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.598678/full