A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies

A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies

Abstract Background The main purpose of dose-finding studies in Phase I trial is to estimate maximum tolerated dose (MTD), which is the maximum test dose that can be assigned with an acceptable level of toxicity. Existing methods developed for single-agent dose-finding assume that the dose-toxicity...

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Bibliographic Details
Main Authors: Niansheng Tang, Songjian Wang, Gen Ye
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Medical Research Methodology
Subjects:
Adaptive rejection Metropolis sampling algorithm
Continual reassessment method
Dirichlet process prior
Dose-finding design
Gibbs sampler
Maximum tolerated dose
Online Access:http://link.springer.com/article/10.1186/s12874-018-0604-9

Internet

http://link.springer.com/article/10.1186/s12874-018-0604-9

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