HRP2 and HRP3 cross-reactivity and implications for HRP2-based RDT use in regions with Plasmodium falciparum hrp2 gene deletions

HRP2 and HRP3 cross-reactivity and implications for HRP2-based RDT use in regions with Plasmodium falciparum hrp2 gene deletions

Abstract Background The Plasmodium falciparum antigen histidine rich protein 2 (HRP2) is a preferred target for malaria rapid diagnostic tests (RDTs) because of its abundant production by the parasite and thermal stability. As a result, a majority of RDTs procured globally target this antigen. Howev...

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Bibliographic Details
Main Authors: Amy Kong, Scott A. Wilson, Yong Ah, Douglas Nace, Eric Rogier, Michael Aidoo
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Malaria Journal
Subjects:
Malaria
RDT
HRP2
HRP3
Cross-reactivity
Gene deletions
Online Access:https://doi.org/10.1186/s12936-021-03739-6

Internet

https://doi.org/10.1186/s12936-021-03739-6

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