HRP2 and HRP3 cross-reactivity and implications for HRP2-based RDT use in regions with Plasmodium falciparum hrp2 gene deletions
Abstract Background The Plasmodium falciparum antigen histidine rich protein 2 (HRP2) is a preferred target for malaria rapid diagnostic tests (RDTs) because of its abundant production by the parasite and thermal stability. As a result, a majority of RDTs procured globally target this antigen. Howev...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-04-01
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Series: | Malaria Journal |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-021-03739-6 |