Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells.

The canonical Wnt/β-catenin pathway is constitutively activated in more than 90% of colorectal cancer (CRC) cases in which β-catenin contributes to CRC cell growth and survival. In contrast to the Wnt/β-catenin pathway, the non-canonical Wnt pathway can antagonize functions of the canonical Wnt/β-ca...

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Bibliographic Details
Main Authors: Tsui-Chin Huang, Pin-Tse Lee, Ming-Heng Wu, Chi-Chen Huang, Chiung-Yuan Ko, Yi-Chao Lee, Ding-Yen Lin, Ya-Wen Cheng, Kuen-Haur Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5578641?pdf=render