Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients.

Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients.

BACKGROUND: Cancer patients carrying mutations in the dihydropyrimidine dehydrogenase gene (DPYD) have a high risk to experience severe drug-adverse effects following chemotherapy with fluoropyrimidine drugs such as 5-fluorouracil (5-FU) or capecitabine. The pretreatment detection of this impairment...

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Bibliographic Details
Main Authors: Eva Gross, Birgit Busse, Matthias Riemenschneider, Steffi Neubauer, Katharina Seck, Hanns-Georg Klein, Marion Kiechle, Florian Lordick, Alfons Meindl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2602733?pdf=render

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http://europepmc.org/articles/PMC2602733?pdf=render

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