Curcumin pretreatment protects against hypoxia/reoxgenation injury via improvement of mitochondrial function, destabilization of HIF-1α and activation of Epac1-Akt pathway in rat bone marrow mesenchymal stem cells

Curcumin pretreatment protects against hypoxia/reoxgenation injury via improvement of mitochondrial function, destabilization of HIF-1α and activation of Epac1-Akt pathway in rat bone marrow mesenchymal stem cells

Bone marrow mesenchymal stem cells (BMSCs) possess promising therapeutic effects and have been considered as a highly desirable agent for tissue injury treatment. However, little survived cells after transplanting due to severe relocated conditions (characterized by prolonged hypoxia and oxidative s...

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Bibliographic Details
Main Authors: Xujie Wang, Yijie Zhang, Yunshu Yang, Wei Zhang, Liang Luo, Fu Han, Hao Guan, Ke Tao, Dahai Hu
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Bone marrow mesenchymal stem cell
Curcumin
Hypoxia/reoxygenation
Mitochondrial function
HIF-1α
Epac1 signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218367490

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http://www.sciencedirect.com/science/article/pii/S0753332218367490

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