An acidic microenvironment increases NK cell killing of Cryptococcus neoformans and Cryptococcus gattii by enhancing perforin degranulation.

An acidic microenvironment increases NK cell killing of Cryptococcus neoformans and Cryptococcus gattii by enhancing perforin degranulation.

Cryptococcus gattii and Cryptococcus neoformans are encapsulated yeasts that can produce a solid tumor-like mass or cryptococcoma. Analogous to malignant tumors, the microenvironment deep within a cryptococcoma is acidic, which presents unique challenges to host defense. Analogous to malignant cells...

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Bibliographic Details
Main Authors: Anowara Islam, Shu Shun Li, Paul Oykhman, Martina Timm-McCann, Shaunna M Huston, Danuta Stack, Richard F Xiang, Margaret M Kelly, Christopher H Mody
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3708852?pdf=render

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http://europepmc.org/articles/PMC3708852?pdf=render

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