Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis

Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: A clue to the pathomechanism of microglial dyshomeostasis

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an autosomal-dominant type of leukoencephalopathy caused by gene mutation of colony stimulating factor 1 receptor, which is expressed mainly on monocyte lineage cells such as monocytes in the peripheral blood and micr...

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Bibliographic Details
Main Authors: Mio Hamatani, Hirofumi Yamashita, Hirofumi Ochi, Shinji Ashida, Yuichiro Hashi, Yoichiro Okada, Chihiro Fujii, Kazuyuki Kawamura, Riko Kitazawa, Masanori Nakagawa, Toshiki Mizuno, Ryosuke Takahashi, Takayuki Kondo
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia
Colony stimulating factor 1 receptor
Flow cytometry
Leukodystrophy
Microglia
Peripheral blood monocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030142X

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http://www.sciencedirect.com/science/article/pii/S096999612030142X

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