Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

Summary: Basal breast cancer is associated with younger age, early relapse, and a high mortality rate. Here, we use unbiased droplet-based single-cell RNA sequencing (RNA-seq) to elucidate the cellular basis of tumor progression during the specification of the basal breast cancer subtype from the lu...

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Bibliographic Details
Main Authors: Fátima Valdés-Mora, Robert Salomon, Brian Stewart Gloss, Andrew Man Kit Law, Jeron Venhuizen, Lesley Castillo, Kendelle Joan Murphy, Astrid Magenau, Michael Papanicolaou, Laura Rodriguez de la Fuente, Daniel Lee Roden, Yolanda Colino-Sanguino, Zoya Kikhtyak, Nona Farbehi, James Ronald William Conway, Neblina Sikta, Samantha Richelle Oakes, Thomas Robert Cox, Seán Ignatius O’Donoghue, Paul Timpson, Christopher John Ormandy, David Gallego-Ortega
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
scRNA-seq
basal breast cancer
alveolar lineage
cancer-associated fibroblast
involution
pregnancy-associated breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472100259X

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http://www.sciencedirect.com/science/article/pii/S221112472100259X

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