Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma

Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma

Genome integrity is protected by the cell-cycle checkpoints that prevent cell proliferation in the presence of DNA damage and allow time for DNA repair. The transient checkpoint arrest together with cellular senescence represent an intrinsic barrier to tumorigenesis. Tumor suppressor p53 is an integ...

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Bibliographic Details
Main Authors: Andra S. Martinikova, Monika Burocziova, Miroslav Stoyanov, Libor Macurek
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
cell-cycle checkpoint
tumor suppressor p53
protein phosphatase
cancer
Online Access:https://www.mdpi.com/2073-4409/9/9/2068

Internet

https://www.mdpi.com/2073-4409/9/9/2068

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