Identification of the PLK2-dependent phosphopeptidome by quantitative proteomics [corrected].

Polo-like kinase 2 (PLK2) has been recently recognized as the major enzyme responsible for phosphorylation of α-synuclein at S129 in vitro and in vivo, suggesting that this kinase may play a key role in the pathogenesis of Parkinson's disease and other synucleinopathies. Moreover PLK2 seems to...

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Bibliographic Details
Main Authors: Cinzia Franchin, Luca Cesaro, Lorenzo A Pinna, Giorgio Arrigoni, Mauro Salvi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0111018