Evaluation of a multi-arm multi-stage Bayesian design for phase II drug selection trials – an example in hemato-oncology

Evaluation of a multi-arm multi-stage Bayesian design for phase II drug selection trials – an example in hemato-oncology

Abstract Background Multi-Arm Multi-Stage designs aim at comparing several new treatments to a common reference, in order to select or drop any treatment arm to move forward when such evidence already exists based on interim analyses. We redesigned a Bayesian adaptive design initially proposed for d...

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Bibliographic Details
Main Authors: Louis Jacob, Maria Uvarova, Sandrine Boulet, Inva Begaj, Sylvie Chevret
Format: Article
Language:English
Published: BMC 2016-06-01
Series:BMC Medical Research Methodology
Subjects:
Bayesian
MAMS
Drop/select drug
Adaptive design
Online Access:http://link.springer.com/article/10.1186/s12874-016-0166-7

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http://link.springer.com/article/10.1186/s12874-016-0166-7

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