Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes

Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes

20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), a product of the cytochrome P450 (CYP)-catalyzed ω-hydroxylation of arachidonic acid, induces oxidative stress and, in clinical studies, is associated with increased body mass index (BMI) and the metabolic syndrome. This study was designed to exa...

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Bibliographic Details
Main Authors: Dong Hyun Kim, Nitin Puri, Komal Sodhi, John R. Falck, Nader G. Abraham, Joseph Shapiro, Michal L. Schwartzman
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Journal of Lipid Research
Subjects:
adipogenesis
arachidonic acid
mesenchymal stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752041942X

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http://www.sciencedirect.com/science/article/pii/S002222752041942X

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