Generation of a heterozygous p53 R249S mutant human embryonic stem cell line by TALEN-mediated genome editing

Generation of a heterozygous p53 R249S mutant human embryonic stem cell line by TALEN-mediated genome editing

Abstract: As one of the most essential genome guardians, p53 and its mutants have been suggested associated with many types of cancers. Many p53 mutants function induce unique phenotypes, including carcinogenesis, metastasis, and drug resistance. The p53(R249S) mutation is the most prevalent and spe...

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Main Authors: Zijun Huo, Jian Tu, An Xu, Yan Li, Donghui Wang, Mo Liu, Ruoji Zhou, Dandan Zhu, Yu Lin, Julian A. Gingold, Chia-Jui Yen, Haipeng Xiao, Ruiying Zhao
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118302903

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http://www.sciencedirect.com/science/article/pii/S1873506118302903

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