Apelin Rejuvenates Aged Human Mesenchymal Stem Cells by Regulating Autophagy and Improves Cardiac Protection After Infarction

Apelin Rejuvenates Aged Human Mesenchymal Stem Cells by Regulating Autophagy and Improves Cardiac Protection After Infarction

The protective effects of mesenchymal stem cell (MSC)-based therapy for myocardial infarction (MI) are largely hampered as they age. Apelin is an endogenous ligand of its receptor APJ and plays an essential role in regulating multiple biological activities including MSC proliferation and survival. I...

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Bibliographic Details
Main Authors: Hao Zhang, Chengling Zhao, Guojun Jiang, Bei Hu, Huifeng Zheng, Yimei Hong, Zhen Cui, Linli Shi, Xin Li, Fang Lin, Yue Ding, Lu Wei, Mimi Li, Xiaoting Liang, Yuelin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
apelin
mesenchymal stem cells
rejuvenation
senescence
myocardial infarction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.628463/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.628463/full

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