Possible Role of IRS-4 in the Origin of Multifocal Hepatocellular Carcinoma

Possible Role of IRS-4 in the Origin of Multifocal Hepatocellular Carcinoma

New evidence suggests that insulin receptor substrate 4 (IRS-4) may play an important role in the promotion of tumoral growth. In this investigation, we have evaluated the role of IRS-4 in a pilot study performed on patients with liver cancer. We used immunohistochemistry to examine IRS-4 expression...

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Bibliographic Details
Main Authors: Luis G. Guijarro, Patricia Sanmartin-Salinas, Eva Pérez-Cuevas, M. Val Toledo-Lobo, Jorge Monserrat, Sofía Zoullas, Miguel A. Sáez, Miguel A. Álvarez-Mon, Julia Bujan, Fernando Noguerales-Fraguas, Eduardo Arilla-Ferreiro, Melchor Álvarez-Mon, Miguel A. Ortega
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
nuclear IRS-4
PI3K
hepatocellular carcinoma
β-catenin
cyclin D
integrin α2/β1 and FAK
Online Access:https://www.mdpi.com/2072-6694/13/11/2560

Internet

https://www.mdpi.com/2072-6694/13/11/2560

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