Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators

Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators

Rationale: The endocannabinoidome mediators, N-Oleoylglycine (OlGly) and N-Oleoylalanine (OlAla), have been shown to reduce acute naloxone-precipitated morphine withdrawal affective and somatic responses.Objectives: To determine the role and mechanism of action of OlGly and OlAla in withdrawal respo...

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Bibliographic Details
Main Authors: Samantha M. Ayoub, Fabiana Piscitelli, Cristoforo Silvestri, Cheryl L. Limebeer, Erin M. Rock, Reem Smoum, Mathew Farag, Hannah de Almeida, Megan T. Sullivan, Sébastien Lacroix, Besma Boubertakh, Nayudu Nallabelli, Aron H Lichtman, Francesco Leri, Raphael Mechoulam, Vincenzo Di Marzo, Linda A. Parker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
oleoyl alanine
oleoyl glycine
opiate withdrawal
endocannabinoidome
somatic withdrawal
heroin self-administration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.706703/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.706703/full

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