Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic Ganglia

Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic Ganglia

Neuroblastoma (NB) is an embryonal malignancy derived from the abnormal differentiation of the sympathetic nervous system. The Anaplastic Lymphoma Kinase (ALK) gene is frequently altered in NB, through copy number alterations and activating mutations, and represents a predisposition in NB-genesis wh...

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Bibliographic Details
Main Authors: Lucie Vivancos Stalin, Marco Gualandi, Johannes Hubertus Schulte, Raffaele Renella, Olga Shakhova, Annick Mühlethaler-Mottet
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
ALK
neuroblastoma
differentiation
sympathetic ganglia
neural crest cells
SOX10
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00275/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00275/full

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