A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo

A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo

Abstract Background A phasic dysregulation of mitochondrial bioenergetics may operate in bipolar disorder, increased in mania and decreased in depression. We aimed to examine efficacy of two add-on treatments in bipolar depression: N-acetylcysteine (NAC) and NAC with a combination of nutraceutical a...

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Bibliographic Details
Main Authors: Michael Berk, Alyna Turner, Gin S. Malhi, Chee H. Ng, Susan M. Cotton, Seetal Dodd, Yuval Samuni, Michelle Tanious, Claire McAulay, Nathan Dowling, Jerome Sarris, Lauren Owen, Astrid Waterdrinker, Deidre Smith, Olivia M. Dean
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Medicine
Subjects:
Mitochondria
Bipolar disorder
Depression
Nutraceutical
Adjunctive
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s12916-019-1257-1

Internet

http://link.springer.com/article/10.1186/s12916-019-1257-1

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