Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells

Abstract The brain produces steroids de novo from cholesterol, so‐called “neurosteroids.” The Purkinje cell, a cerebellar neuron, was discovered as a major site of the biosynthesis of neurosteroids including sex steroids, such as progesterone, from cholesterol in the brain. Allopregnanolone, a proge...

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Bibliographic Details
Main Authors: Kazuyoshi Tsutsui, Shogo Haraguchi
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:FASEB BioAdvances
Subjects:
Online Access:https://doi.org/10.1096/fba.2019-00055