Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells
Abstract The brain produces steroids de novo from cholesterol, so‐called “neurosteroids.” The Purkinje cell, a cerebellar neuron, was discovered as a major site of the biosynthesis of neurosteroids including sex steroids, such as progesterone, from cholesterol in the brain. Allopregnanolone, a proge...
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Online Access: | https://doi.org/10.1096/fba.2019-00055 |
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doaj-ea69672aceb64c2d913b2dccec85cefc2020-11-25T00:32:37ZengWileyFASEB BioAdvances2573-98322020-03-012314915910.1096/fba.2019-00055Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cellsKazuyoshi Tsutsui0Shogo Haraguchi1Laboratory of Integrative Brain Sciences Department of Biology Waseda University Center for Medical Life Science of Waseda University Tokyo JapanLaboratory of Integrative Brain Sciences Department of Biology Waseda University Center for Medical Life Science of Waseda University Tokyo JapanAbstract The brain produces steroids de novo from cholesterol, so‐called “neurosteroids.” The Purkinje cell, a cerebellar neuron, was discovered as a major site of the biosynthesis of neurosteroids including sex steroids, such as progesterone, from cholesterol in the brain. Allopregnanolone, a progesterone metabolite, is also synthesized in the cerebellum and acts on the Purkinje cell to prevent cell death of this neuron. Recently, the pineal gland was discovered as an important site of the biosynthesis of neurosteroids. Allopregnanolone, a major pineal neurosteroid, acts on the Purkinje cell for the survival of this neuron by suppressing the expression of caspase‐3, a crucial mediator of apoptosis. This review summarizes the discovery of cerebellar and pineal allopregnanolone and its neuroprotective action on Purkinje cells.https://doi.org/10.1096/fba.2019-00055allopregnanolonebrain and pineal glandneuronal survivalprogesteronePurkinje cell |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kazuyoshi Tsutsui Shogo Haraguchi |
spellingShingle |
Kazuyoshi Tsutsui Shogo Haraguchi Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells FASEB BioAdvances allopregnanolone brain and pineal gland neuronal survival progesterone Purkinje cell |
author_facet |
Kazuyoshi Tsutsui Shogo Haraguchi |
author_sort |
Kazuyoshi Tsutsui |
title |
Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells |
title_short |
Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells |
title_full |
Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells |
title_fullStr |
Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells |
title_full_unstemmed |
Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells |
title_sort |
neuroprotective actions of cerebellar and pineal allopregnanolone on purkinje cells |
publisher |
Wiley |
series |
FASEB BioAdvances |
issn |
2573-9832 |
publishDate |
2020-03-01 |
description |
Abstract The brain produces steroids de novo from cholesterol, so‐called “neurosteroids.” The Purkinje cell, a cerebellar neuron, was discovered as a major site of the biosynthesis of neurosteroids including sex steroids, such as progesterone, from cholesterol in the brain. Allopregnanolone, a progesterone metabolite, is also synthesized in the cerebellum and acts on the Purkinje cell to prevent cell death of this neuron. Recently, the pineal gland was discovered as an important site of the biosynthesis of neurosteroids. Allopregnanolone, a major pineal neurosteroid, acts on the Purkinje cell for the survival of this neuron by suppressing the expression of caspase‐3, a crucial mediator of apoptosis. This review summarizes the discovery of cerebellar and pineal allopregnanolone and its neuroprotective action on Purkinje cells. |
topic |
allopregnanolone brain and pineal gland neuronal survival progesterone Purkinje cell |
url |
https://doi.org/10.1096/fba.2019-00055 |
work_keys_str_mv |
AT kazuyoshitsutsui neuroprotectiveactionsofcerebellarandpinealallopregnanoloneonpurkinjecells AT shogoharaguchi neuroprotectiveactionsofcerebellarandpinealallopregnanoloneonpurkinjecells |
_version_ |
1725319880562966528 |