Cardiomyocyte Deletion of Bmal1 Exacerbates QT- and RR-Interval Prolongation in Scn5a+/ΔKPQ Mice

Cardiomyocyte Deletion of Bmal1 Exacerbates QT- and RR-Interval Prolongation in Scn5a+/ΔKPQ Mice

Circadian rhythms are generated by cell autonomous circadian clocks that perform a ubiquitous cellular time-keeping function and cell type-specific functions important for normal physiology. Studies show inducing the deletion of the core circadian clock transcription factor Bmal1 in adult mouse card...

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Bibliographic Details
Main Authors: Elizabeth A. Schroder, Jennifer L. Wayland, Kaitlyn M. Samuels, Syed F. Shah, Don E. Burgess, Tanya Seward, Claude S. Elayi, Karyn A. Esser, Brian P. Delisle
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
heart
electrophysiology
ion channel
SCN5A
long QT syndrome
Bmal1
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.681011/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.681011/full

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