Understanding the specificity of human Galectin-8C domain interactions with its glycan ligands based on molecular dynamics simulations.

Human Galectin-8 (Gal-8) is a member of the galectin family which shares an affinity for β-galactosides. The tandem-repeat Gal-8 consists of a N- and a C-terminal carbohydrate recognition domain (N- and C-CRD) joined by a linker peptide of various length. Despite their structural similarity both CRD...

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Bibliographic Details
Main Authors: Sonu Kumar, Martin Frank, Reinhard Schwartz-Albiez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3612102?pdf=render