Opposing Effects of TGFβ and BMP in the Pulmonary Vasculature in Congenital Diaphragmatic Hernia

Opposing Effects of TGFβ and BMP in the Pulmonary Vasculature in Congenital Diaphragmatic Hernia

Background: Pulmonary hypertension is the major cause of morbidity and mortality in congenital diaphragmatic hernia (CDH). Mutations in several genes that encode signaling molecules of the transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways have previously been associat...

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Bibliographic Details
Main Authors: Daphne S. Mous, Marjon J. Buscop-van Kempen, Rene M. H. Wijnen, Dick Tibboel, Rory E. Morty, Robbert J. Rottier
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Medicine
Subjects:
lung
vasculature
BMP
TGF
congenital diagraphma hernia
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.642577/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.642577/full

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