Deprivation of Muscleblind-Like Proteins Causes Deficits in Cortical Neuron Distribution and Morphological Changes in Dendritic Spines and Postsynaptic Densities

Deprivation of Muscleblind-Like Proteins Causes Deficits in Cortical Neuron Distribution and Morphological Changes in Dendritic Spines and Postsynaptic Densities

Myotonic dystrophy (Dystrophia Myotonica; DM) is the most common adult-onset muscular dystrophy and its brain symptoms seriously affect patients’ quality of life. It is caused by extended (CTG)n expansions at 3′-UTR of DMPK gene (DM type 1, DM1) or (CCTG)n repeats in the intron 1 of CNBP gene (DM ty...

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Bibliographic Details
Main Authors: Kuang-Yung Lee, Ho-Ching Chang, Carol Seah, Li-Jen Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neuroanatomy
Subjects:
muscleblind-like knockouts
myotonic dystrophy
cortical neurons
interneurons
dendrites
postsynaptic densities
Online Access:https://www.frontiersin.org/article/10.3389/fnana.2019.00075/full

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https://www.frontiersin.org/article/10.3389/fnana.2019.00075/full

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