A Peptide Vaccine Candidate Tailored to Individuals' Genetics Mimics the Multi-Targeted T Cell Immunity of COVID-19 Convalescent Subjects

A Peptide Vaccine Candidate Tailored to Individuals' Genetics Mimics the Multi-Targeted T Cell Immunity of COVID-19 Convalescent Subjects

Long-term immunity to coronaviruses likely stems from T cell activity. We present here a novel approach for the selection of immunoprevalent SARS-CoV-2-derived T cell epitopes using an in silico cohort of HLA-genotyped individuals with different ethnicities. Nine 30-mer peptides derived from the fou...

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Bibliographic Details
Main Authors: Eszter Somogyi, Zsolt Csiszovszki, Levente Molnár, Orsolya Lőrincz, József Tóth, Sofie Pattijn, Jana Schockaert, Aurélie Mazy, István Miklós, Katalin Pántya, Péter Páles, Enikő R. Tőke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Genetics
Subjects:
global vaccine
HLA-genotype
ethnic diversity
SARS-CoV-2 immunity
in silico clinical trial
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.684152/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.684152/full

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