Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.

Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.

In the interest of identification of new kinase-targeting chemotypes for target and pathway analysis and drug discovery in Trypanosomal brucei, a high-throughput screen of 42,444 focused inhibitors from the GlaxoSmithKline screening collection was performed against parasite cell cultures and counter...

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Bibliographic Details
Main Authors: Rosario Diaz, Sandra A Luengo-Arratta, João D Seixas, Emanuele Amata, William Devine, Carlos Cordon-Obras, Domingo I Rojas-Barros, Elena Jimenez, Fatima Ortega, Sabrinia Crouch, Gonzalo Colmenarejo, Jose Maria Fiandor, Jose Julio Martin, Manuela Berlanga, Silvia Gonzalez, Pilar Manzano, Miguel Navarro, Michael P Pollastri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4207660?pdf=render

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http://europepmc.org/articles/PMC4207660?pdf=render

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