NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.

Kaposi's sarcoma-associated herpesvirus (KSHV) latently infects host cells and establishes lifelong persistence as an extra-chromosomal episome in the nucleus. To persist in proliferating cells, the viral genome typically replicates once per cell cycle and is distributed into daughter cells. Th...

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Bibliographic Details
Main Authors: Fang Zhang, Deguang Liang, Xiaoxi Lin, Zhe Zou, Rui Sun, Xing Wang, Xiaozhen Liang, Kenneth M Kaye, Ke Lan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007628